Sickle Cell Disease (SCD) is one of the most well researched and understood genetic blood disorders. Despite this, its impact is profound both clinically and socially. At its core lies a single nucleotide polymorphism (SNP), just one nucleotide change is all that’s required for such significant downstream effects ranging from red cell morphological changes to global health schemes. This post takes a walk through that journey from the SNP through to the sickling and how such a small change can lead to such a big problem.